The zero draft of South Africa’s next National Strategic Plan on HIV, TB, STIs is being shared for review and comment in the midst of ongoing national consultations and consideration by technical working groups. This version is informed by consultation and research to date, while remaining open to forthcoming inputs. The content is not comprehensive nor is it finalised; key targets and priority actions are still being discussed. This is a strategic document, with detailed thematic monographs which accompany the final product. Operational and implementation plans will be developed at a later stage. The NSP development team welcomes feedback of any kind on the zero draft at this stage.